2RKF

HIV-1 PR resistant mutant + LPV

2RKF の概要

• エントリーDOI: 10.2210/pdb2rkf/pdb
• 分子名称: PROTEASE RETROPEPSIN, SULFATE ION, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, ... (5 entities in total)
• 機能のキーワード: resistence, insertion, hydrolase
• 由来する生物種: human immunodeficiency virus 1 (HIV-1)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22572.43

構造登録者

Rezacova, P.,Brynda, J.,Kozisek, M.,Saskova, K.G.,Konvalinka, J. (登録日: 2007-10-16, 公開日: 2008-08-05, 最終更新日: 2023-08-30)

• 主引用文献: Kozisek, M.,Saskova, K.G.,Rezacova, P.,Brynda, J.,van Maarseveen, N.M.,De Jong, D.,Boucher, C.A.,Kagan, R.M.,Nijhuis, M.,Konvalinka, J.; Ninety-nine is not enough: molecular characterization of inhibitor-resistant human immunodeficiency virus type 1 protease mutants with insertions in the flap region; J.Virol., 82:5869-5878, 2008; PubMed: 18400858; DOI: 10.1128/JVI.02325-07

実験手法

X-RAY DIFFRACTION (1.8 Å)