2RJS

SgTAM bound to substrate mimic

Summary for 2RJS

Entry DOI	10.2210/pdb2rjs/pdb
Related	2OHY 2QVE 2RJR
Descriptor	Tyrosine aminomutase, (3R)-3-amino-2,2-difluoro-3-(4-methoxyphenyl)propanoic acid (3 entities in total)
Functional Keywords	4-methylidene imidazole, mio, aminomutase, c-1027, isomerase
Biological source	Streptomyces globisporus
Total number of polymer chains	2
Total formula weight	116799.92
Authors	Montavon, T.J.,Christianson, C.V.,Bruner, S.D. (deposition date: 2007-10-15, release date: 2008-01-15, Last modification date: 2024-10-30)
Primary citation	Montavon, T.J.,Christianson, C.V.,Festin, G.M.,Shen, B.,Bruner, S.D. Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM. Bioorg.Med.Chem.Lett., 18:3099-3102, 2008 Cited by PubMed Abstract: The synthesis and evaluation of two classes of inhibitors for SgTAM, a 4-methylideneimidazole-5-one (MIO) containing tyrosine aminomutase, are described. A mechanism-based strategy was used to design analogs that mimic the substrate or product of the reaction and form covalent interactions with the enzyme through the MIO prosthetic group. The analogs were characterized by measuring inhibition constants and X-ray crystallographic structural analysis of the co-complexes bound to the aminomutase, SgTAM. PubMed: 18078753 DOI: 10.1016/j.bmcl.2007.11.046 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation