2RJ6

B-specific alpha-1,3-galactosyltransferase G176R S235G mutant (AABB) + H-antigen disaccharide

2RJ6 の概要

• エントリーDOI: 10.2210/pdb2rj6/pdb
• 関連するPDBエントリー: 2RIT 2RIX 2RIY 2RIZ 2RJ0 2RJ1 2RJ4 2RJ5 2RJ7 2RJ8 2RJ9
• 分子名称: Glycoprotein-fucosylgalactoside alpha-galactosyltransferase, octyl 2-O-(6-deoxy-alpha-L-galactopyranosyl)-beta-D-galactopyranoside (3 entities in total)
• 機能のキーワード: aabb+ha, blood group antigen, glycoprotein, glycosyltransferase, golgi apparatus, manganese, membrane, metal-binding, secreted, signal-anchor, transferase, transmembrane
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein: P16442
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34794.18

構造登録者

Evans, S.V.,Alfaro, J.A. (登録日: 2007-10-14, 公開日: 2008-02-05, 最終更新日: 2024-02-21)

• 主引用文献: Alfaro, J.A.,Zheng, R.B.,Persson, M.,Letts, J.A.,Polakowski, R.,Bai, Y.,Borisova, S.N.,Seto, N.O.,Lowary, T.L.,Palcic, M.M.,Evans, S.V.; ABO(H) blood group A and B glycosyltransferases recognize substrate via specific conformational changes.; J.Biol.Chem., 283:10097-10108, 2008; PubMed: 18192272; DOI: 10.1074/jbc.M708669200

実験手法

X-RAY DIFFRACTION (1.41 Å)