2RGS

FC-fragment of monoclonal antibody IGG2B from Mus musculus

2RGS の概要

• エントリーDOI: 10.2210/pdb2rgs/pdb
• 分子名称: Ig gamma-2B heavy chain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: fc-fragment, immunoglobulin, glycosylation, immune system
• 由来する生物種: Mus musculus (mouse)
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass membrane protein (Potential). Isoform 2: Secreted: P01867
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 52312.55

構造登録者

Kolenko, P.,Duskova, J.,Skalova, T.,Dohnalek, J.,Hasek, J. (登録日: 2007-10-05, 公開日: 2008-10-07, 最終更新日: 2023-08-30)

• 主引用文献: Kolenko, P.,Dohnalek, J.,Duskova, J.,Skalova, T.,Collard, R.,Hasek, J.; New insights into intra- and intermolecular interactions of immunoglobulins: crystal structure of mouse IgG2b-Fc at 2.1-A resolution; Immunology, 126:378-385, 2008; PubMed: 18783468; DOI: 10.1111/j.1365-2567.2008.02904.x

実験手法

X-RAY DIFFRACTION (2.13 Å)