2RGF

RBD OF RAL GUANOSINE-NUCLEOTIDE EXCHANGE FACTOR (PROTEIN), NMR, 10 STRUCTURES

2RGF の概要

• エントリーDOI: 10.2210/pdb2rgf/pdb
• 分子名称: RALGEF-RBD (1 entity in total)
• 機能のキーワード: ras-binding domain, ralgef, ralgds, ras, rbd
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11136.64

構造登録者

Geyer, M.,Herrmann, C.,Wittinghofer, A.,Kalbitzer, H.R. (登録日: 1997-02-13, 公開日: 1998-03-04, 最終更新日: 2024-05-22)

主引用文献

Geyer, M.,Herrmann, C.,Wohlgemuth, S.,Wittinghofer, A.,Kalbitzer, H.R.
Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling.
Nat.Struct.Biol., 4:694-699, 1997

PubMed Abstract: The solution structure of the Ras-binding domain (RBD) of Ral guanine-nucleotide exchange factor RalGEF was solved by NMR spectroscopy. The overall structure is similar to that of Raf-RBD, another effector of Ras, although the sequence identity is only 13%. 15N chemical shifts changes in the complex of RalGEF-RBD with Ras indicate an interaction similar to the intermolecular beta-sheet observed for the complex between Ras and Raf-RBD.

PubMed: 9302994
DOI: 10.1038/nsb0997-694

実験手法

SOLUTION NMR