2RF3

Crystal Structure of Tricyclo-DNA: An Unusual Compensatory Change of Two Adjacent Backbone Torsion Angles

2RF3 の概要

• エントリーDOI: 10.2210/pdb2rf3/pdb
• 分子名称: 5'-d(CGCG(TCY)ATTCGCG)-3', ZINC ION, SPERMINE, ... (4 entities in total)
• 機能のキーワード: dna duplex, x-ray crystal structure, tricyclo-dna, conformationally constrained dna analog, dna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7670.63

構造登録者

Pallan, P.S.,Ittig, D.,Heroux, A.,Wawrzak, Z.,Leumann, C.J.,Egli, M. (登録日: 2007-09-27, 公開日: 2008-02-12, 最終更新日: 2023-08-30)

主引用文献

Pallan, P.S.,Ittig, D.,Heroux, A.,Wawrzak, Z.,Leumann, C.J.,Egli, M.
Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles.
Chem.Commun.(Camb.), 2008:883-885, 2008

PubMed Abstract: The crystal structure of a DNA duplex with tricyclo-DNA (tc-DNA) residues explains the increased RNA affinity of tc-DNA relative to DNA and tc-DNA's superior resistance to nucleases.

PubMed: 18253536
DOI: 10.1039/b716390h

実験手法

X-RAY DIFFRACTION (1.75 Å)