2RF2

HIV reverse transcriptase in complex with inhibitor 7e (NNRTI)

2RF2 の概要

• エントリーDOI: 10.2210/pdb2rf2/pdb
• 分子名称: Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p66 RT), 5-bromo-3-(pyrrolidin-1-ylsulfonyl)-1H-indole-2-carboxamide, ... (4 entities in total)
• 機能のキーワード: hiv-1 revers transcriptase, ais, non-nucleoside inhibition, nucleotidyltransferase, aids, aspartyl protease, capsid maturation, core protein, cytoplasm, dna integration, dna recombination, dna-directed dna polymerase, endonuclease, host-virus interaction, hydrolase, lipoprotein, magnesium, membrane, metal-binding, multifunctional enzyme, myristate, nuclease, nucleus, phosphorylation, protease, rna-binding, rna-directed dna polymerase, viral nucleoprotein, virion, zinc, zinc-finger, transferase
• 由来する生物種: HIV-1 M:B_HXB2R; 詳細
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 116998.97

構造登録者

Yan, Y.,Prasad, S. (登録日: 2007-09-27, 公開日: 2008-01-01, 最終更新日: 2023-08-30)

• 主引用文献: Zhao, Z.,Wolkenberg, S.E.,Lu, M.,Munshi, V.,Moyer, G.,Feng, M.,Carella, A.V.,Ecto, L.T.,Gabryelski, L.J.,Lai, M.T.,Prasad, S.G.,Yan, Y.,McGaughey, G.B.,Miller, M.D.,Lindsley, C.W.,Hartman, G.D.,Vacca, J.P.,Williams, T.M.; Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs).; Bioorg.Med.Chem.Lett., 18:554-559, 2008; PubMed: 18083561; DOI: 10.1016/j.bmcl.2007.11.085

実験手法

X-RAY DIFFRACTION (2.4 Å)