2RBE

The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors

2RBE の概要

• エントリーDOI: 10.2210/pdb2rbe/pdb
• 分子名称: Corticosteroid 11-beta-dehydrogenase isozyme 1, (5R)-2-[(2-fluorophenyl)amino]-5-(1-methylethyl)-1,3-thiazol-4(5H)-one, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• 機能のキーワード: alpha beta, 3-layer(aba) sandwich, rossmann fold, nad(p)-binding rossmann-like domain, endoplasmic reticulum, glycoprotein, lipid metabolism, membrane, microsome, nadp, oxidoreductase, signal-anchor, steroid metabolism, transmembrane, polymorphism
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane ; Single-pass type II membrane protein : P28845
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 125936.62

構造登録者

Zhang, J.,Jordan, S.R.,Li, V. (登録日: 2007-09-18, 公開日: 2008-01-15, 最終更新日: 2024-02-21)

• 主引用文献: Yuan, C.,St Jean, D.J.,Liu, Q.,Cai, L.,Li, A.,Han, N.,Moniz, G.,Askew, B.,Hungate, R.W.,Johansson, L.,Tedenborg, L.,Pyring, D.,Williams, M.,Hale, C.,Chen, M.,Cupples, R.,Zhang, J.,Jordan, S.,Bartberger, M.D.,Sun, Y.,Emery, M.,Wang, M.,Fotsch, C.; The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors.; Bioorg.Med.Chem.Lett., 17:6056-6061, 2007; PubMed: 17919905; DOI: 10.1016/j.bmcl.2007.09.070

実験手法

X-RAY DIFFRACTION (1.9 Å)