2RAN

RAT ANNEXIN V CRYSTAL STRUCTURE: CA2+-INDUCED CONFORMATIONAL CHANGES

2RAN の概要

• エントリーDOI: 10.2210/pdb2ran/pdb
• 分子名称: ANNEXIN V, CALCIUM ION, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: calcium/phospholipid-binding protein, calcium-phospholipid-binding protein complex
• 由来する生物種: Rattus norvegicus (Norway rat)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35899.76

構造登録者

Concha, N.O.,Head, J.F.,Kaetzel, M.A.,Dedman, J.R.,Seaton, B.A. (登録日: 1994-09-01, 公開日: 1994-11-30, 最終更新日: 2024-02-21)

主引用文献

Concha, N.O.,Head, J.F.,Kaetzel, M.A.,Dedman, J.R.,Seaton, B.A.
Rat annexin V crystal structure: Ca(2+)-induced conformational changes.
Science, 261:1321-1324, 1993

PubMed Abstract: Annexins are a family of calcium- and phospholipid-binding proteins implicated in mediating membrane-related processes such as secretion, signal transduction, and ion channel activity. The crystal structure of rat annexin V was solved to 1.9 angstrom resolution by multiple isomorphous replacement. Unlike previously solved annexin V structures, all four domains bound calcium in this structure. Calcium binding in the third domain induced a large relocation of the calcium-binding loop regions, exposing the single tryptophan residue to the solvent. These alterations in annexin V suggest a role for domain 3 in calcium-triggered interaction with phospholipid membranes.

PubMed: 8362244

実験手法

X-RAY DIFFRACTION (1.89 Å)