2R9S

c-Jun N-terminal Kinase 3 with 3,5-Disubstituted Quinoline inhibitor

Summary for 2R9S

Entry DOI	10.2210/pdb2r9s/pdb
Descriptor	Mitogen-activated protein kinase 10, N-(tert-butyl)-4-[5-(pyridin-2-ylamino)quinolin-3-yl]benzenesulfonamide, UNKNOWN ATOM OR ION, ... (6 entities in total)
Functional Keywords	jnk3, signaling protein, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P53779
Total number of polymer chains	2
Total formula weight	84035.11
Authors	Habel, J. (deposition date: 2007-09-13, release date: 2007-10-16, Last modification date: 2023-08-30)
Primary citation	Jiang, R.,Duckett, D.,Chen, W.,Habel, J.,Ling, Y.Y.,LoGrasso, P.,Kamenecka, T.M. 3,5-Disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors. Bioorg.Med.Chem.Lett., 17:6378-6382, 2007 Cited by PubMed: 17911023 DOI: 10.1016/j.bmcl.2007.08.054 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation