2R8Q

Structure of LmjPDEB1 in complex with IBMX

Summary for 2R8Q

• Entry DOI: 10.2210/pdb2r8q/pdb
• Descriptor: Class I phosphodiesterase PDEB1, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: leishimaniasis, parasite inhibitor selectivity, camp phosphodiesterase, hydrolase
• Biological source: Leishmania major
• Total number of polymer chains: 2
• Total formula weight: 81751.76

Authors

Wang, H.,Yan, Z.,Geng, J.,Kunz, S.,Seebeck, T.,Ke, H. (deposition date: 2007-09-11, release date: 2007-12-18, Last modification date: 2024-04-03)

• Primary citation: Wang, H.,Yan, Z.,Geng, J.,Kunz, S.,Seebeck, T.,Ke, H.; Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors.; Mol.Microbiol., 66:1029-1038, 2007; PubMed: 17944832; DOI: 10.1111/j.1365-2958.2007.05976.x

Experimental method

X-RAY DIFFRACTION (1.5 Å)