2R64
Crystal structure of a 3-aminoindazole compound with CDK2
Summary for 2R64
Entry DOI | 10.2210/pdb2r64/pdb |
Related | 2DUV |
Descriptor | Cell division protein kinase 2, N-[5-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-1H-INDAZOL-3-YL]-2-(4-PIPERIDIN-1-YLPHENYL)ACETAMIDE (3 entities in total) |
Functional Keywords | protein kinase, inhibitor, cell division, atp-binding, cell cycle, mitosis, nucleotide-binding, phosphorylation, polymorphism, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens |
Total number of polymer chains | 1 |
Total formula weight | 34430.04 |
Authors | Lee, J.,Choi, H.,Kim, K.H.,Jeong, S.,Park, J.W.,Baek, C.S.,Lee, S.H. (deposition date: 2007-09-05, release date: 2008-09-09, Last modification date: 2024-03-13) |
Primary citation | Lee, J.,Choi, H.,Kim, K.H.,Jeong, S.,Park, J.W.,Baek, C.S.,Lee, S.H. Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors. Bioorg.Med.Chem.Lett., 18:2292-2295, 2008 Cited by PubMed: 18353638DOI: 10.1016/j.bmcl.2008.03.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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