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2R64

Crystal structure of a 3-aminoindazole compound with CDK2

Summary for 2R64
Entry DOI10.2210/pdb2r64/pdb
Related2DUV
DescriptorCell division protein kinase 2, N-[5-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-1H-INDAZOL-3-YL]-2-(4-PIPERIDIN-1-YLPHENYL)ACETAMIDE (3 entities in total)
Functional Keywordsprotein kinase, inhibitor, cell division, atp-binding, cell cycle, mitosis, nucleotide-binding, phosphorylation, polymorphism, serine/threonine-protein kinase, transferase
Biological sourceHomo sapiens
Total number of polymer chains1
Total formula weight34430.04
Authors
Lee, J.,Choi, H.,Kim, K.H.,Jeong, S.,Park, J.W.,Baek, C.S.,Lee, S.H. (deposition date: 2007-09-05, release date: 2008-09-09, Last modification date: 2024-03-13)
Primary citationLee, J.,Choi, H.,Kim, K.H.,Jeong, S.,Park, J.W.,Baek, C.S.,Lee, S.H.
Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors.
Bioorg.Med.Chem.Lett., 18:2292-2295, 2008
Cited by
PubMed: 18353638
DOI: 10.1016/j.bmcl.2008.03.002
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

217705

数据于2024-03-27公开中

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