2R64

Crystal structure of a 3-aminoindazole compound with CDK2

2R64 の概要

• エントリーDOI: 10.2210/pdb2r64/pdb
• 関連するPDBエントリー: 2DUV
• 分子名称: Cell division protein kinase 2, N-[5-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-1H-INDAZOL-3-YL]-2-(4-PIPERIDIN-1-YLPHENYL)ACETAMIDE (3 entities in total)
• 機能のキーワード: protein kinase, inhibitor, cell division, atp-binding, cell cycle, mitosis, nucleotide-binding, phosphorylation, polymorphism, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34430.04

構造登録者

Lee, J.,Choi, H.,Kim, K.H.,Jeong, S.,Park, J.W.,Baek, C.S.,Lee, S.H. (登録日: 2007-09-05, 公開日: 2008-09-09, 最終更新日: 2024-03-13)

主引用文献

Lee, J.,Choi, H.,Kim, K.H.,Jeong, S.,Park, J.W.,Baek, C.S.,Lee, S.H.
Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors.
Bioorg.Med.Chem.Lett., 18:2292-2295, 2008

PubMed Abstract: A novel series of 3,5-diaminoindazoles were prepared and found to be CDK inhibitors. Potent inhibitors against CDK1 and CDK2 were obtained by introduction of 1lambda(6)-isothiazolidine-1,1-dioxide at 5-position of indazole. Anti-proliferative activities of compounds were evaluated using EJ, HCT116, SW620, and A549 cancer cell lines.

PubMed: 18353638
DOI: 10.1016/j.bmcl.2008.03.002

実験手法

X-RAY DIFFRACTION (2.3 Å)