Crystal Structure of the two MBT repeats from Sex-Comb on Midleg (SCM) in complex with peptide R-(me)K-S

Summary for 2R5M

Related2R57 2R58 2R5A
DescriptorPolycomb protein Scm, peptide R(me)KS (3 entities in total)
Functional Keywordsmbt repeat, polycomb, sex comb on midleg, chromatin regulator, developmental protein, metal-binding, nucleus, repressor, transcription, transcription regulation
Biological sourceDrosophila melanogaster (fruit fly)
Cellular locationNucleus (Probable) Q9VHA0
Total number of polymer chains2
Total molecular weight29802.79
Grimm, C.,Steuerwald, U.,Mueller, C.W. (deposition date: 2007-09-04, release date: 2007-10-30, Last modification date: 2011-07-13)
Primary citation
Grimm, C.,de Ayala Alonso, A.G.,Rybin, V.,Steuerwald, U.,Ly-Hartig, N.,Fischle, W.,Muller, J.,Muller, C.W.
Structural and functional analyses of methyl-lysine binding by the malignant brain tumour repeat protein Sex comb on midleg.
Embo Rep., 8:1031-1037, 2007
PubMed: 17932512 (PDB entries with the same primary citation)
DOI: 10.1038/sj.embor.7401085
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23260.5%7.2%4.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2r5m
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Molmil generated image of 2r5m
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Molmil generated image of 2r5m
rotated about y axis by 90°