2R59
Leukotriene A4 hydrolase complexed with inhibitor RB3041
Summary for 2R59
Entry DOI | 10.2210/pdb2r59/pdb |
Related | 1GW6 1H19 1HS6 1SQM |
Descriptor | Leukotriene A-4 hydrolase, ZINC ION, YTTERBIUM (III) ION, ... (6 entities in total) |
Functional Keywords | transition state, analogue peptide, hydrolysis, alternative splicing, cytoplasm, hydrolase, leukotriene biosynthesis, metal-binding, metalloprotease, multifunctional enzyme, protease, zinc |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 70854.67 |
Authors | Tholander, F.,Haeggstrom, J.Z.,Thunnissen, M.,Muroya, A.,Roques, B.P.,Fournie-Zaluski, M.C. (deposition date: 2007-09-03, release date: 2008-08-12, Last modification date: 2024-04-03) |
Primary citation | Tholander, F.,Muroya, A.,Roques, B.P.,Fournie-Zaluski, M.C.,Thunnissen, M.M.,Haeggstrom, J.Z. Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design. Chem.Biol., 15:920-929, 2008 Cited by PubMed: 18804029DOI: 10.1016/j.chembiol.2008.07.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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