2R3T
I50V HIV-1 protease mutant in complex with a carbamoyl decorated pyrrolidine-based inhibitor
Summary for 2R3T
Entry DOI | 10.2210/pdb2r3t/pdb |
Related | 2R38 2R3W 2R43 |
Descriptor | Protease, CHLORIDE ION, 4,4'-{(3S,4S)-PYRROLIDINE-3,4-DIYLBIS[(BENZYLIMINO)SULFONYL]}DIBENZAMIDE, ... (4 entities in total) |
Functional Keywords | protein-ligand complex, aspartyl protease, hydrolase, protease |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22262.67 |
Authors | Boettcher, J.,Blum, A.,Heine, A.,Diederich, W.E.,Klebe, G. (deposition date: 2007-08-30, release date: 2008-09-02, Last modification date: 2023-08-30) |
Primary citation | Bottcher, J.,Blum, A.,Heine, A.,Diederich, W.E.,Klebe, G. Structural and Kinetic Analysis of Pyrrolidine-Based Inhibitors of the Drug-Resistant Ile84Val Mutant of HIV-1 Protease J.Mol.Biol., 383:347-357, 2008 Cited by PubMed: 18692068DOI: 10.1016/j.jmb.2008.07.062 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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