2R3L

Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor

2R3L の概要

• エントリーDOI: 10.2210/pdb2r3l/pdb
• 関連するPDBエントリー: 2R3F 2R3G 2R3H 2R3I 2R3J 2R3K 2R3M 2R3N 2R3O 2R3P 2R3Q 2R3R
• 分子名称: Cell division protein kinase 2, 3-bromo-6-phenyl-N-(pyrimidin-5-ylmethyl)imidazo[1,2-a]pyridin-8-amine (3 entities in total)
• 機能のキーワード: serine/threonine-protein kinase, cell cycle, inhibition, cyclin-dependent kinase, cancer, atp-binding, cell division, mitosis, nucleotide-binding, phosphorylation, polymorphism, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34414.77

構造登録者

Fischmann, T.O.,Hruza, A.W.,Madison, V.M.,Duca, J.S. (登録日: 2007-08-29, 公開日: 2008-01-22, 最終更新日: 2011-07-13)

• 主引用文献: Fischmann, T.O.,Hruza, A.,Duca, J.S.,Ramanathan, L.,Mayhood, T.,Windsor, W.T.,Le, H.V.,Guzi, T.J.,Dwyer, M.P.,Paruch, K.,Doll, R.J.,Lees, E.,Parry, D.,Seghezzi, W.,Madison, V.; Structure-guided discovery of cyclin-dependent kinase inhibitors.; Biopolymers, 89:372-379, 2008; PubMed: 17937404; DOI: 10.1002/bip.20868

実験手法

X-RAY DIFFRACTION (1.65 Å)