2QZR

tRNA-Guanine Transglycosylase(TGT) in Complex with 6-amino-2-[(1-naphthylmethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one

2QZR の概要

• エントリーDOI: 10.2210/pdb2qzr/pdb
• 関連するPDBエントリー: 1P0E 1PUD 1Y5V 1Y5W 1Y5X 2BBF
• 分子名称: Queuine tRNA-ribosyltransferase, ZINC ION, 6-amino-2-[(1-naphthylmethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, ... (5 entities in total)
• 機能のキーワード: transferase, glycosyltransferase, metal-binding, queuosine biosynthesis, trna processing
• 由来する生物種: Zymomonas mobilis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43400.49

構造登録者

Hoertner, S.R.,Ritschel, T.,Stengl, B.,Kramer, C.,Schweizer, W.B.,Wagner, B.,Kansy, M.,Klebe, G.,Diederich, F. (登録日: 2007-08-17, 公開日: 2007-09-11, 最終更新日: 2023-08-30)

• 主引用文献: Hortner, S.R.,Ritschel, T.,Stengl, B.,Kramer, C.,Schweizer, W.B.,Wagner, B.,Kansy, M.,Klebe, G.,Diederich, F.; Potent Inhibitors of tRNA-Guanine Transglycosylase, an Enzyme Linked to the Pathogenicity of the Shigella Bacterium: Charge-Assisted Hydrogen Bonding.; Angew.Chem.Int.Ed.Engl., 46:8266-8269, 2007; PubMed: 17902085; DOI: 10.1002/anie.200702961

実験手法

X-RAY DIFFRACTION (1.95 Å)