2QY0

Active dimeric structure of the catalytic domain of C1r reveals enzyme-product like contacts

Summary for 2QY0

Entry DOI	10.2210/pdb2qy0/pdb
Descriptor	Complement C1r subcomponent, GLYCEROL, ... (4 entities in total)
Functional Keywords	complement, serine protease, beta barrel, complement pathway, egf-like domain, glycoprotein, hydrolase, hydroxylation, immune response, innate immunity, phosphorylation, sushi
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	91851.70
Authors	Kardos, J.,Harmat, V.,Pallo, A.,Barabas, O.,Szilagyi, K.,Graf, L.,Naray-Szabo, G.,Goto, Y.,Zavodszky, P.,Gal, P. (deposition date: 2007-08-13, release date: 2008-02-05, Last modification date: 2023-08-30)
Primary citation	Kardos, J.,Harmat, V.,Pallo, A.,Barabas, O.,Szilagyi, K.,Graf, L.,Naray-Szabo, G.,Goto, Y.,Zavodszky, P.,Gal, P. Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: Structure of the active catalytic region of C1r. Mol.Immunol., 45:1752-1760, 2008 Cited by PubMed: 17996945 DOI: 10.1016/j.molimm.2007.09.031 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation