2QY0

Active dimeric structure of the catalytic domain of C1r reveals enzyme-product like contacts

2QY0 の概要

• エントリーDOI: 10.2210/pdb2qy0/pdb
• 分子名称: Complement C1r subcomponent, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: complement, serine protease, beta barrel, complement pathway, egf-like domain, glycoprotein, hydrolase, hydroxylation, immune response, innate immunity, phosphorylation, sushi
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 91851.70

構造登録者

Kardos, J.,Harmat, V.,Pallo, A.,Barabas, O.,Szilagyi, K.,Graf, L.,Naray-Szabo, G.,Goto, Y.,Zavodszky, P.,Gal, P. (登録日: 2007-08-13, 公開日: 2008-02-05, 最終更新日: 2023-08-30)

• 主引用文献: Kardos, J.,Harmat, V.,Pallo, A.,Barabas, O.,Szilagyi, K.,Graf, L.,Naray-Szabo, G.,Goto, Y.,Zavodszky, P.,Gal, P.; Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: Structure of the active catalytic region of C1r.; Mol.Immunol., 45:1752-1760, 2008; PubMed: 17996945; DOI: 10.1016/j.molimm.2007.09.031

実験手法

X-RAY DIFFRACTION (2.6 Å)