2QXH

Crystal Structure of Human Kallikrein 7 in Complex with Suc-Ala-Ala-Pro-Phe-chloromethylketone

Summary for 2QXH

Entry DOI	10.2210/pdb2qxh/pdb
Related	2QXG 2QXI 2QXJ
Descriptor	Kallikrein-7, N-(3-carboxypropanoyl)-L-alanyl-L-alanyl-N-[(2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl]-L-prolinamide (3 entities in total)
Functional Keywords	70-80 loop, active site inhibitor, chloromethyl ketone, alternative splicing, glycoprotein, hydrolase, protease, secreted, serine protease, zymogen
Biological source	Homo sapiens (human)
Cellular location	Secreted: P49862
Total number of polymer chains	1
Total formula weight	25020.18
Authors	Debela, M.,Hess, P.,Magdolen, V.,Schechter, N.M.,Bode, W.,Goettig, P. (deposition date: 2007-08-11, release date: 2008-01-08, Last modification date: 2023-08-30)
Primary citation	Debela, M.,Hess, P.,Magdolen, V.,Schechter, N.M.,Steiner, T.,Huber, R.,Bode, W.,Goettig, P. Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7. Proc.Natl.Acad.Sci.Usa, 104:16086-16091, 2007 Cited by PubMed: 17909180 DOI: 10.1073/pnas.0707811104 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation