2QX1

Crystal structure of the complex between mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FABH) and decyl-COA disulfide

2QX1 の概要

• エントリーDOI: 10.2210/pdb2qx1/pdb
• 関連するPDBエントリー: 1HNJ 1HNK 1HZP 1U6E 1U6S
• 分子名称: Beta-ketoacyl-ACP synthase III, COENZYME A, DECANE-1-THIOL, ... (4 entities in total)
• 機能のキーワード: fatty acid biosynthesis, myobacterium tuberculosis, structural basis for substrate specificity, enzyme inhibitor complex, mechanism based inhibitor, acyltransferase, lipid synthesis, multifunctional enzyme, transferase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70923.01

構造登録者

Sachdeva, S.,Musayev, F.,Alhamadsheh, M.,Scarsdale, J.N.,Wright, H.T.,Reynolds, K.A. (登録日: 2007-08-10, 公開日: 2008-03-18, 最終更新日: 2023-08-30)

• 主引用文献: Sachdeva, S.,Musayev, F.,Alhamadsheh, M.M.,Neel Scarsdale, J.,Tonie Wright, H.,Reynolds, K.A.; Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates; Bioorg.Chem., 36:85-90, 2008; PubMed: 18096200; DOI: 10.1016/j.bioorg.2007.11.001

実験手法

X-RAY DIFFRACTION (2.6 Å)