2QVD

Identification of a potent anti-inflammatory agent from the natural extract of plant Cardiospermun helicacabum: Crystal structure of the complex of phospholipase A2 with Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy at 1.93 A resolution

Summary for 2QVD

• Entry DOI: 10.2210/pdb2qvd/pdb
• Related: 2OYF 2PYC
• Descriptor: Phospholipase A2 VRV-PL-VIIIa, BERBERINE (3 entities in total)
• Functional Keywords: phospholipids, membrane, hydrolysis, inhibitor, plant extraxt, lipid degradation, metal-binding, neurotoxin, presynaptic neurotoxin, secreted, toxin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Daboia russellii pulchella (Russell's viper)
• Cellular location: Secreted: P59071
• Total number of polymer chains: 1
• Total formula weight: 13966.13

Authors

Kumar, S.,Chandra, D.N.,Singh, N.,Jithesh, O.,Sharma, S.,Haridas, M.,Singh, T.P. (deposition date: 2007-08-08, release date: 2007-08-21, Last modification date: 2023-10-25)

• Primary citation: Chandra, D.N.,Prasanth, G.K.,Singh, N.,Kumar, S.,Jithesh, O.,Sadasivan, C.,Sharma, S.,Singh, T.P.,Haridas, M.; Identification of a novel and potent inhibitor of phospholipase A(2) in a medicinal plant: crystal structure at 1.93A and Surface Plasmon Resonance analysis of phospholipase A(2) complexed with berberine; Biochim.Biophys.Acta, 1814:657-663, 2011; PubMed: 21420512; DOI: 10.1016/j.bbapap.2011.03.002

Experimental method

X-RAY DIFFRACTION (1.93 Å)