2QVD
Identification of a potent anti-inflammatory agent from the natural extract of plant Cardiospermun helicacabum: Crystal structure of the complex of phospholipase A2 with Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy at 1.93 A resolution
2QVD の概要
エントリーDOI | 10.2210/pdb2qvd/pdb |
関連するPDBエントリー | 2OYF 2PYC |
分子名称 | Phospholipase A2 VRV-PL-VIIIa, BERBERINE (3 entities in total) |
機能のキーワード | phospholipids, membrane, hydrolysis, inhibitor, plant extraxt, lipid degradation, metal-binding, neurotoxin, presynaptic neurotoxin, secreted, toxin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Daboia russellii pulchella (Russell's viper) |
細胞内の位置 | Secreted: P59071 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 13966.13 |
構造登録者 | Kumar, S.,Chandra, D.N.,Singh, N.,Jithesh, O.,Sharma, S.,Haridas, M.,Singh, T.P. (登録日: 2007-08-08, 公開日: 2007-08-21, 最終更新日: 2023-10-25) |
主引用文献 | Chandra, D.N.,Prasanth, G.K.,Singh, N.,Kumar, S.,Jithesh, O.,Sadasivan, C.,Sharma, S.,Singh, T.P.,Haridas, M. Identification of a novel and potent inhibitor of phospholipase A(2) in a medicinal plant: crystal structure at 1.93A and Surface Plasmon Resonance analysis of phospholipase A(2) complexed with berberine Biochim.Biophys.Acta, 1814:657-663, 2011 Cited by PubMed: 21420512DOI: 10.1016/j.bbapap.2011.03.002 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.93 Å) |
構造検証レポート
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