2QU2

BACE1 with Compound 1

Summary for 2QU2

• Entry DOI: 10.2210/pdb2qu2/pdb
• Related: 2QU3
• Descriptor: Beta-secretase 1, N-[amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide (3 entities in total)
• Functional Keywords: bace1, inhibitor, acylguanidine, alternative splicing, aspartyl protease, glycoprotein, hydrolase, membrane, protease, transmembrane, zymogen
• Biological source: Homo sapiens (Human)
• Cellular location: Membrane; Single-pass type I membrane protein: P56817
• Total number of polymer chains: 1
• Total formula weight: 46759.35

Authors

Chopra, R. (deposition date: 2007-08-03, release date: 2008-08-05, Last modification date: 2011-07-13)

• Primary citation: Fobare, W.F.,Solvibile, W.R.,Robichaud, A.J.,Malamas, M.S.,Manas, E.,Turner, J.,Hu, Y.,Wagner, E.,Chopra, R.,Cowling, R.,Jin, G.,Bard, J.; Thiophene substituted acylguanidines as BACE1 inhibitors.; Bioorg.Med.Chem.Lett., 17:5353-5356, 2007; PubMed: 17761418; DOI: 10.1016/j.bmcl.2007.08.010

Experimental method

X-RAY DIFFRACTION (2.6 Å)