2QTW
The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals structural homology to Resistin within the C-terminal domain
Summary for 2QTW
Entry DOI | 10.2210/pdb2qtw/pdb |
Descriptor | Proprotein convertase subtilisin/kexin type 9 Propeptide, Proprotein convertase subtilisin/kexin type 9, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | pro-protein convertase, coronary heart disease, hypercholesterolemia, low density lipoprotein receptor, autocatalytic cleavage, cholesterol metabolism, disease mutation, glycoprotein, hydrolase, lipid metabolism, phosphorylation, protease, secreted, serine protease, steroid metabolism, zymogen |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 72553.64 |
Authors | Hampton, E.N.,Knuth, M.W.,Li, J.,Harris, J.L.,Lesley, S.A.,Spraggon, G. (deposition date: 2007-08-02, release date: 2007-09-18, Last modification date: 2024-10-16) |
Primary citation | Hampton, E.N.,Knuth, M.W.,Li, J.,Harris, J.L.,Lesley, S.A.,Spraggon, G. The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain. Proc.Natl.Acad.Sci.Usa, 104:14604-14609, 2007 Cited by PubMed: 17804797DOI: 10.1073/pnas.0703402104 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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