2QTW

The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals structural homology to Resistin within the C-terminal domain

2QTW の概要

• エントリーDOI: 10.2210/pdb2qtw/pdb
• 分子名称: Proprotein convertase subtilisin/kexin type 9 Propeptide, Proprotein convertase subtilisin/kexin type 9, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: pro-protein convertase, coronary heart disease, hypercholesterolemia, low density lipoprotein receptor, autocatalytic cleavage, cholesterol metabolism, disease mutation, glycoprotein, hydrolase, lipid metabolism, phosphorylation, protease, secreted, serine protease, steroid metabolism, zymogen
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72553.64

構造登録者

Hampton, E.N.,Knuth, M.W.,Li, J.,Harris, J.L.,Lesley, S.A.,Spraggon, G. (登録日: 2007-08-02, 公開日: 2007-09-18, 最終更新日: 2020-07-29)

• 主引用文献: Hampton, E.N.,Knuth, M.W.,Li, J.,Harris, J.L.,Lesley, S.A.,Spraggon, G.; The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain.; Proc.Natl.Acad.Sci.Usa, 104:14604-14609, 2007; PubMed: 17804797; DOI: 10.1073/pnas.0703402104

実験手法

X-RAY DIFFRACTION (1.9 Å)