2QTL

Crystal Structure of the FAD-containing FNR-like Module of Human Methionine Synthase Reductase

2QTL の概要

• エントリーDOI: 10.2210/pdb2qtl/pdb
• 関連するPDBエントリー: 2QTZ
• 分子名称: Methionine synthase reductase, FLAVIN-ADENINE DINUCLEOTIDE (3 entities in total)
• 機能のキーワード: alpha-beta-alpha structural motif, flattened antiparallel beta barrel, flexible hinge region, connecting domain, fad-binding region, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform B: Cytoplasm. Isoform C: Cytoplasm. Isoform A: Cytoplasm : Q9UBK8
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 60858.07

構造登録者

Wolthers, K.R.,Lou, X.,Toogood, H.S.,Leys, D.,Scrutton, N.S. (登録日: 2007-08-02, 公開日: 2007-11-13, 最終更新日: 2022-12-21)

• 主引用文献: Wolthers, K.R.,Lou, X.,Toogood, H.S.,Leys, D.,Scrutton, N.S.; Mechanism of Coenzyme Binding to Human Methionine Synthase Reductase Revealed through the Crystal Structure of the FNR-like Module and Isothermal Titration Calorimetry; Biochemistry, 46:11833-11844, 2007; PubMed: 17892308; DOI: 10.1021/bi701209p

実験手法

X-RAY DIFFRACTION (1.9 Å)