2QT0

Human nicotinamide riboside kinase 1 in complex with nicotinamide riboside and an ATP analogue

Summary for 2QT0

• Entry DOI: 10.2210/pdb2qt0/pdb
• Related: 2QSY 2QSZ 2QT1
• Descriptor: Nicotinamide riboside kinase 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
• Functional Keywords: non-protein kinase, nad+, nicotinamide riboside, nrk1, nicotinamide riboside kinase activity, nicotinic acid riboside kinase activity, nad biosynthesis, pyridine nucleotide biosynthesis, atp analogue, structural genomics, structural genomics consortium, sgc, alternative splicing, atp-binding, nucleotide-binding, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 25159.12

Authors

Rabeh, W.M.,Tempel, W.,Nedyalkova, L.,Landry, R.,Arrowsmith, C.H.,Edwards, A.M.,Sundstrom, M.,Weigelt, J.,Bochkarev, A.,Brenner, C.,Park, H.,Structural Genomics Consortium (SGC) (deposition date: 2007-07-31, release date: 2007-08-14, Last modification date: 2023-11-15)

• Primary citation: Tempel, W.,Rabeh, W.M.,Bogan, K.L.,Belenky, P.,Wojcik, M.,Seidle, H.F.,Nedyalkova, L.,Yang, T.,Sauve, A.A.,Park, H.W.,Brenner, C.; Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD(+).; Plos Biol., 5:e263-e263, 2007; PubMed: 17914902; DOI: 10.1371/journal.pbio.0050263

Experimental method

X-RAY DIFFRACTION (1.92 Å)