2QSC

Crystal structure analysis of anti-HIV-1 V3-Fab F425-B4e8 in complex with a V3-peptide

2QSC の概要

• エントリーDOI: 10.2210/pdb2qsc/pdb
• 分子名称: Fab F425-B4e8, Light chain, Fab F425-B4e8, Heavy chain, Envelope glycoprotein gp120, ... (7 entities in total)
• 機能のキーワード: fab-peptide complex, hiv-1, gp120, v3 loop, immunoglobulin fold, aids, apoptosis, envelope protein, fusion protein, glycoprotein, host-virus interaction, membrane, transmembrane, viral immunoevasion, virion, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 49822.08

構造登録者

Bell, C.H.,Schiefner, A.,Stanfield, R.L.,Wilson, I.A. (登録日: 2007-07-30, 公開日: 2008-01-15, 最終更新日: 2020-07-29)

• 主引用文献: Bell, C.H.,Pantophlet, R.,Schiefner, A.,Cavacini, L.A.,Stanfield, R.L.,Burton, D.R.,Wilson, I.A.; Structure of antibody F425-B4e8 in complex with a V3 peptide reveals a new binding mode for HIV-1 neutralization.; J.Mol.Biol., 375:969-978, 2008; PubMed: 18068724; DOI: 10.1016/j.jmb.2007.11.013

実験手法

X-RAY DIFFRACTION (2.8 Å)