2QRH

Glycogen Phosphorylase b in complex with (1R)-3'-phenylspiro[1,5-anhydro-D-glucitol-1,5'-isoxazoline]

2QRH の概要

• エントリーDOI: 10.2210/pdb2qrh/pdb
• 関連するPDBエントリー: 2QRG
• 分子名称: Glycogen phosphorylase, muscle form, (5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-phenyl-1,6-dioxa-2-azaspiro[4.5]dec-2-ene-8,9,10-triol (3 entities in total)
• 機能のキーワード: glycogenolysis, type 2 diabetes, acetylation, allosteric enzyme, carbohydrate metabolism, glycogen metabolism, glycosyltransferase, nucleotide-binding, phosphorylation, pyridoxal phosphate, transferase
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 97814.61

構造登録者

Kizilis, G.,Alexacou, K.-M.,Chrysina, E.D.,Zographos, S.E.,Leonidas, D.D.,Oikonomakos, N.G. (登録日: 2007-07-28, 公開日: 2008-08-05, 最終更新日: 2023-11-15)

• 主引用文献: Benltifa, M.,Hayes, J.M.,Vidal, S.,Gueyrard, D.,Goekjian, P.G.,Praly, J.P.,Kizilis, G.,Tiraidis, C.,Alexacou, K.M.,Chrysina, E.D.,Zographos, S.E.,Leonidas, D.D.,Archontis, G.,Oikonomakos, N.G.; Glucose-based spiro-isoxazolines: a new family of potent glycogen phosphorylase inhibitors.; Bioorg.Med.Chem., 17:7368-7380, 2009; PubMed: 19781947; DOI: 10.1016/j.bmc.2009.08.060

実験手法

X-RAY DIFFRACTION (1.83 Å)