2QR9

Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain Complexed with an Oxabicyclic Derivative Compound

2QR9 の概要

• エントリーDOI: 10.2210/pdb2qr9/pdb
• 関連するPDBエントリー: 2QSE 2QXM
• 分子名称: Estrogen receptor, Nuclear receptor coactivator 2, dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate, ... (4 entities in total)
• 機能のキーワード: protein-ligand complex, dna-binding, lipid-binding, metal-binding, nucleus, phosphorylation, receptor, steroid-binding, transcription, transcription regulation, zinc-finger
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372; Nucleus : Q8BN74
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 62721.70

構造登録者

Nettles, K.W.,Bruning, J.B. (登録日: 2007-07-27, 公開日: 2008-03-18, 最終更新日: 2023-08-30)

• 主引用文献: Nettles, K.W.,Bruning, J.B.,Gil, G.,Nowak, J.,Sharma, S.K.,Hahm, J.B.,Kulp, K.,Hochberg, R.B.,Zhou, H.,Katzenellenbogen, J.A.,Katzenellenbogen, B.S.,Kim, Y.,Joachmiak, A.,Greene, G.L.; NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses; Nat.Chem.Biol., 4:241-247, 2008; PubMed: 18344977; DOI: 10.1038/nchembio.76

実験手法

X-RAY DIFFRACTION (2 Å)