2QR8

2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2 (RSK2)

Summary for 2QR8

Entry DOI	10.2210/pdb2qr8/pdb
Related	2QR7
Descriptor	Ribosomal protein S6 kinase alpha-3, SODIUM ION (3 entities in total)
Functional Keywords	kinase domain, rsk2, autoinhibitory, atp-binding, nucleotide-binding, phosphorylation, serine/threonine-protein kinase, transferase
Biological source	Mus musculus (house mouse)
Cellular location	Nucleus (By similarity): P18654
Total number of polymer chains	1
Total formula weight	38501.92
Authors	Tereshko, V.,Malakhova, M.,Dong, Z. (deposition date: 2007-07-27, release date: 2007-12-11, Last modification date: 2024-11-06)
Primary citation	Malakhova, M.,Tereshko, V.,Lee, S.Y.,Yao, K.,Cho, Y.-Y.,Bode, A.,Dong, Z. Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2. Nat.Struct.Mol.Biol., 15:112-113, 2008 Cited by PubMed Abstract: The X-ray structure at 2.0-A resolution of the p90 ribosomal S6 kinase 2 C-terminal kinase domain revealed a C-terminal autoinhibitory alphaL-helix that was embedded in the kinase scaffold and determines the inactive kinase conformation. We suggest a mechanism of activation through displacement of the alphaL-helix and rearrangement of the conserved residue Glu500, as well as the reorganization of the T-loop into the active conformation. PubMed: 18084304 DOI: 10.1038/nsmb1347 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation