2QR7

2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2: Se-Met derivative

Summary for 2QR7

• Entry DOI: 10.2210/pdb2qr7/pdb
• Related: 2QR8
• Descriptor: Ribosomal protein S6 kinase alpha-3, SODIUM ION (3 entities in total)
• Functional Keywords: kinase domain, rsk2, autoinhibitory, atp-binding, nucleotide-binding, phosphorylation, serine/threonine-protein kinase, transferase
• Biological source: Mus musculus (house mouse)
• Cellular location: Nucleus (By similarity): P18654
• Total number of polymer chains: 1
• Total formula weight: 38830.18

Authors

Malakhova, M.,Tereshko, V.,Dong, Z. (deposition date: 2007-07-27, release date: 2007-12-11, Last modification date: 2024-10-30)

Primary citation

Malakhova, M.,Tereshko, V.,Lee, S.Y.,Yao, K.,Cho, Y.-Y.,Bode, A.,Dong, Z.
Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2.
Nat.Struct.Mol.Biol., 15:112-113, 2008

PubMed Abstract: The X-ray structure at 2.0-A resolution of the p90 ribosomal S6 kinase 2 C-terminal kinase domain revealed a C-terminal autoinhibitory alphaL-helix that was embedded in the kinase scaffold and determines the inactive kinase conformation. We suggest a mechanism of activation through displacement of the alphaL-helix and rearrangement of the conserved residue Glu500, as well as the reorganization of the T-loop into the active conformation.

PubMed: 18084304
DOI: 10.1038/nsmb1347

Experimental method

X-RAY DIFFRACTION (2 Å)