2QR7

2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2: Se-Met derivative

2QR7 の概要

• エントリーDOI: 10.2210/pdb2qr7/pdb
• 関連するPDBエントリー: 2QR8
• 分子名称: Ribosomal protein S6 kinase alpha-3, SODIUM ION (3 entities in total)
• 機能のキーワード: kinase domain, rsk2, autoinhibitory, atp-binding, nucleotide-binding, phosphorylation, serine/threonine-protein kinase, transferase
• 由来する生物種: Mus musculus (house mouse)
• 細胞内の位置: Nucleus (By similarity): P18654
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38830.18

構造登録者

Malakhova, M.,Tereshko, V.,Dong, Z. (登録日: 2007-07-27, 公開日: 2007-12-11, 最終更新日: 2024-10-30)

主引用文献

Malakhova, M.,Tereshko, V.,Lee, S.Y.,Yao, K.,Cho, Y.-Y.,Bode, A.,Dong, Z.
Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2.
Nat.Struct.Mol.Biol., 15:112-113, 2008

PubMed Abstract: The X-ray structure at 2.0-A resolution of the p90 ribosomal S6 kinase 2 C-terminal kinase domain revealed a C-terminal autoinhibitory alphaL-helix that was embedded in the kinase scaffold and determines the inactive kinase conformation. We suggest a mechanism of activation through displacement of the alphaL-helix and rearrangement of the conserved residue Glu500, as well as the reorganization of the T-loop into the active conformation.

PubMed: 18084304
DOI: 10.1038/nsmb1347

実験手法

X-RAY DIFFRACTION (2 Å)