2QOE
Human Dipeptidyl Peptidase IV in complex with a Triazolopiperazine-based beta amino acid Inhibitor
Summary for 2QOE
Entry DOI | 10.2210/pdb2qoe/pdb |
Descriptor | Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | alpha/beta inhibitors, beta-propeller, dimer, diabetes, aminopeptidase, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, signal-anchor, transmembrane |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 174523.41 |
Authors | Scapin, G. (deposition date: 2007-07-20, release date: 2007-11-06, Last modification date: 2021-10-20) |
Primary citation | Kowalchick, J.E.,Leiting, B.,Pryor, K.D.,Marsilio, F.,Wu, J.K.,He, H.,Lyons, K.A.,Eiermann, G.J.,Petrov, A.,Scapin, G.,Patel, R.A.,Thornberry, N.A.,Weber, A.E.,Kim, D. Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors. Bioorg.Med.Chem.Lett., 17:5934-5939, 2007 Cited by PubMed: 17827003DOI: 10.1016/j.bmcl.2007.07.100 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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