2QOE

Human Dipeptidyl Peptidase IV in complex with a Triazolopiperazine-based beta amino acid Inhibitor

2QOE の概要

• エントリーDOI: 10.2210/pdb2qoe/pdb
• 分子名称: Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: alpha/beta inhibitors, beta-propeller, dimer, diabetes, aminopeptidase, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, signal-anchor, transmembrane
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 174523.41

構造登録者

Scapin, G. (登録日: 2007-07-20, 公開日: 2007-11-06, 最終更新日: 2021-10-20)

• 主引用文献: Kowalchick, J.E.,Leiting, B.,Pryor, K.D.,Marsilio, F.,Wu, J.K.,He, H.,Lyons, K.A.,Eiermann, G.J.,Petrov, A.,Scapin, G.,Patel, R.A.,Thornberry, N.A.,Weber, A.E.,Kim, D.; Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors.; Bioorg.Med.Chem.Lett., 17:5934-5939, 2007; PubMed: 17827003; DOI: 10.1016/j.bmcl.2007.07.100

実験手法

X-RAY DIFFRACTION (2.3 Å)