2QNJ

Kinase and Ubiquitin-associated domains of MARK3/Par-1

2QNJ の概要

• エントリーDOI: 10.2210/pdb2qnj/pdb
• 分子名称: MAP/microtubule affinity-regulating kinase 3 (2 entities in total)
• 機能のキーワード: serine/threonine protein kinase, ubiquitin-associated domain, mark, par-1, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane ; Peripheral membrane protein : P27448
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75337.13

構造登録者

Murphy, J.M.,Ceccarelli, D.F.J.,Sicheri, F.,Pawson, T. (登録日: 2007-07-18, 公開日: 2007-09-04, 最終更新日: 2023-08-30)

• 主引用文献: Murphy, J.M.,Korzhnev, D.M.,Ceccarelli, D.F.,Briant, D.J.,Zarrine-Afsar, A.,Sicheri, F.,Kay, L.E.,Pawson, T.; Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain; Proc.Natl.Acad.Sci.Usa, 104:14336-14341, 2007; PubMed: 17726107; DOI: 10.1073/pnas.0703012104

実験手法

X-RAY DIFFRACTION (2.7 Å)