2QMQ

Crystal structure of a n-myc downstream regulated 2 protein (ndrg2, syld, ndr2, ai182517, au040374) from mus musculus at 1.70 A resolution

2QMQ の概要

• エントリーDOI: 10.2210/pdb2qmq/pdb
• 分子名称: Protein NDRG2, MAGNESIUM ION, BENZOIC ACID, ... (5 entities in total)
• 機能のキーワード: alpha/beta-hydrolases fold, ndr family, developmental protein, differentiation, neurogenesis, phosphorylation, regulatory protein, structural genomics, joint center for structural genomics, jcsg, protein structure initiative, psi-2, signaling protein
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32595.41

構造登録者

Joint Center for Structural Genomics (JCSG) (登録日: 2007-07-16, 公開日: 2007-09-04, 最終更新日: 2023-09-20)

主引用文献

Hwang, J.,Kim, Y.,Kang, H.B.,Jaroszewski, L.,Deacon, A.M.,Lee, H.,Choi, W.C.,Kim, K.J.,Kim, C.H.,Kang, B.S.,Lee, J.O.,Oh, T.K.,Kim, J.W.,Wilson, I.A.,Kim, M.H.
Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor.
J.Biol.Chem., 286:12450-12460, 2011

PubMed Abstract: Considerable attention has recently been paid to the N-Myc downstream-regulated gene (NDRG) family because of its potential as a tumor suppressor in many human cancers. Primary amino acid sequence information suggests that the NDRG family proteins may belong to the α/β-hydrolase (ABH) superfamily; however, their functional role has not yet been determined. Here, we present the crystal structures of the human and mouse NDRG2 proteins determined at 2.0 and 1.7 Å resolution, respectively. Both NDRG2 proteins show remarkable structural similarity to the ABH superfamily, despite limited sequence similarity. Structural analysis suggests that NDRG2 is a nonenzymatic member of the ABH superfamily, because it lacks the catalytic signature residues and has an occluded substrate-binding site. Several conserved structural features suggest NDRG may be involved in molecular interactions. Mutagenesis data based on the structural analysis support a crucial role for helix α6 in the suppression of TCF/β-catenin signaling in the tumorigenesis of human colorectal cancer, via a molecular interaction.

PubMed: 21247902
DOI: 10.1074/jbc.M110.170803

実験手法

X-RAY DIFFRACTION (1.7 Å)