2QJ9

Crystal structure analysis of BMP-2 in complex with BMPR-IA variant B1

Summary for 2QJ9

Entry DOI	10.2210/pdb2qj9/pdb
Related	1ES7 1RWE 2QJA 2QJB 3BMP
Descriptor	Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA (3 entities in total)
Functional Keywords	ligand-receptor complex, chondrogenesis, cleavage on pair of basic residues, cytokine, developmental protein, differentiation, glycoprotein, growth factor, osteogenesis, atp-binding, disease mutation, kinase, magnesium, manganese, membrane, metal-binding, nucleotide-binding, phosphorylation, serine/threonine-protein kinase, transferase, transmembrane, cytokine-receptor complex, cytokine/receptor
Biological source	Homo sapiens (human) More
Cellular location	Membrane; Single-pass type I membrane protein: P12643 Secreted: P36894
Total number of polymer chains	4
Total formula weight	55727.19
Authors	Kotzsch, A.,Mueller, T.D. (deposition date: 2007-07-06, release date: 2008-01-15, Last modification date: 2023-08-30)
Primary citation	Kotzsch, A.,Nickel, J.,Seher, A.,Heinecke, K.,van Geersdaele, L.,Herrmann, T.,Sebald, W.,Mueller, T.D. Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome. J.Biol.Chem., 283:5876-5887, 2008 Cited by PubMed: 18160401 DOI: 10.1074/jbc.M706029200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.44 Å)

Structure validation