2QJ9

Crystal structure analysis of BMP-2 in complex with BMPR-IA variant B1

2QJ9 の概要

• エントリーDOI: 10.2210/pdb2qj9/pdb
• 関連するPDBエントリー: 1ES7 1RWE 2QJA 2QJB 3BMP
• 分子名称: Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA (3 entities in total)
• 機能のキーワード: ligand-receptor complex, chondrogenesis, cleavage on pair of basic residues, cytokine, developmental protein, differentiation, glycoprotein, growth factor, osteogenesis, atp-binding, disease mutation, kinase, magnesium, manganese, membrane, metal-binding, nucleotide-binding, phosphorylation, serine/threonine-protein kinase, transferase, transmembrane, cytokine-receptor complex, cytokine/receptor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P12643; Secreted: P36894
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 55727.19

構造登録者

Kotzsch, A.,Mueller, T.D. (登録日: 2007-07-06, 公開日: 2008-01-15, 最終更新日: 2023-08-30)

• 主引用文献: Kotzsch, A.,Nickel, J.,Seher, A.,Heinecke, K.,van Geersdaele, L.,Herrmann, T.,Sebald, W.,Mueller, T.D.; Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome.; J.Biol.Chem., 283:5876-5887, 2008; PubMed: 18160401; DOI: 10.1074/jbc.M706029200

実験手法

X-RAY DIFFRACTION (2.44 Å)