2QG2
HSP90 complexed with A917985
Summary for 2QG2
Entry DOI | 10.2210/pdb2qg2/pdb |
Related | 2QF6 2QFO 2QG0 |
Descriptor | Heat shock protein HSP 90-alpha, 3-({2-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)ETHYNYL]BENZYL}AMINO)-1,3-OXAZOL-2(3H)-ONE (3 entities in total) |
Functional Keywords | protein-inhibitor complex, chaperone |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P07900 |
Total number of polymer chains | 1 |
Total formula weight | 23469.58 |
Authors | Park, C.H. (deposition date: 2007-06-28, release date: 2008-07-01, Last modification date: 2023-08-30) |
Primary citation | Huth, J.R.,Park, C.,Petros, A.M.,Kunzer, A.R.,Wendt, M.D.,Wang, X.,Lynch, C.L.,Mack, J.C.,Swift, K.M.,Judge, R.A.,Chen, J.,Richardson, P.L.,Jin, S.,Tahir, S.K.,Matayoshi, E.D.,Dorwin, S.A.,Ladror, U.S.,Severin, J.M.,Walter, K.A.,Bartley, D.M.,Fesik, S.W.,Elmore, S.W.,Hajduk, P.J. Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies. Chem.Biol.Drug Des., 70:1-12, 2007 Cited by PubMed: 17630989DOI: 10.1111/j.1747-0285.2007.00535.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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