2QFR
Crystal structure of red kidney bean purple acid phosphatase with bound sulfate
Summary for 2QFR
| Entry DOI | 10.2210/pdb2qfr/pdb |
| Related | 2qfp 3kbp 4kbp |
| Descriptor | Purple acid phosphatase, FE (III) ION, ZINC ION, ... (7 entities in total) |
| Functional Keywords | binuclear metal centre, substrate analog, hydrolase |
| Biological source | Phaseolus vulgaris (Kidney bean) |
| Total number of polymer chains | 2 |
| Total formula weight | 101020.66 |
| Authors | Guddat, L.W.,Schenk, G.,Gahan, L.R.,Elliot, T.W.,Leung, E. (deposition date: 2007-06-27, release date: 2008-10-14, Last modification date: 2024-11-06) |
| Primary citation | Schenk, G.,Elliott, T.W.,Leung, E.,Carrington, L.E.,Mitic, N.,Gahan, L.R.,Guddat, L.W. Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle. Bmc Struct.Biol., 8:6-6, 2008 Cited by PubMed Abstract: Purple acid phosphatases belong to the family of binuclear metallohydrolases and are involved in a multitude of biological functions, ranging from bacterial killing and bone metabolism in animals to phosphate uptake in plants. Due to its role in bone resorption purple acid phosphatase has evolved into a promising target for the development of anti-osteoporotic chemotherapeutics. The design of specific and potent inhibitors for this enzyme is aided by detailed knowledge of its reaction mechanism. However, despite considerable effort in the last 10 years various aspects of the basic molecular mechanism of action are still not fully understood. PubMed: 18234116DOI: 10.1186/1472-6807-8-6 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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