2QFO

HSP90 complexed with A143571 and A516383

Summary for 2QFO

Entry DOI	10.2210/pdb2qfo/pdb
Descriptor	Heat shock protein HSP 90-alpha, 4-METHYL-6-(TRIFLUOROMETHYL)PYRIMIDIN-2-AMINE, (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one, ... (4 entities in total)
Functional Keywords	protein-inhibitor complex, atp-binding, chaperone, nucleotide-binding, phosphoprotein, stress response
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P07900
Total number of polymer chains	2
Total formula weight	46634.78
Authors	Park, C.H. (deposition date: 2007-06-27, release date: 2008-07-01, Last modification date: 2023-08-30)
Primary citation	Huth, J.R.,Park, C.,Petros, A.M.,Kunzer, A.R.,Wendt, M.D.,Wang, X.,Lynch, C.L.,Mack, J.C.,Swift, K.M.,Judge, R.A.,Chen, J.,Richardson, P.L.,Jin, S.,Tahir, S.K.,Matayoshi, E.D.,Dorwin, S.A.,Ladror, U.S.,Severin, J.M.,Walter, K.A.,Bartley, D.M.,Fesik, S.W.,Elmore, S.W.,Hajduk, P.J. Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies. CHEM.BIOL.DRUG DES., 70:1-12, 2007 Cited by PubMed: 17630989 DOI: 10.1111/j.1747-0285.2007.00535.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.68 Å)

Structure validation