2QEX

Negamycin Binds to the Wall of the Nascent Chain Exit Tunnel of the 50S Ribosomal Subunit

2QEX の概要

• エントリーDOI: 10.2210/pdb2qex/pdb
• 分子名称: 23S ribosomal RNA, 50S ribosomal protein L10e, 50S ribosomal protein L13P, ... (38 entities in total)
• 機能のキーワード: large ribosomal subunit, 50s, negamycin, haloarcula marismortui, ribosome
• 由来する生物種: Haloarcula marismortui; 詳細
• 細胞内の位置: Cytoplasm : P12743
• タンパク質・核酸の鎖数: 31
• 化学式量合計: 1431015.30

構造登録者

Schroeder, S.J.,Blaha, G. (登録日: 2007-06-26, 公開日: 2008-09-30, 最終更新日: 2023-08-30)

主引用文献

Schroeder, S.J.,Blaha, G.,Moore, P.B.
Negamycin binds to the wall of the nascent chain exit tunnel of the 50S ribosomal subunit.
Antimicrob.Agents Chemother., 51:4462-4465, 2007

PubMed Abstract: Negamycin, a small-molecule inhibitor of protein synthesis, binds the Haloarcula marismortui 50S ribosomal subunit at a single site formed by highly conserved RNA nucleotides near the cytosolic end of the nascent chain exit tunnel. The mechanism of antibiotic action and the function of this unexplored tunnel region remain intriguingly elusive.

PubMed: 17664317
DOI: 10.1128/AAC.00455-07

実験手法

X-RAY DIFFRACTION (2.9 Å)