2QCF

Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (Asp312Asn mutant) of human UMP synthase bound to 5-fluoro-UMP

2QCF の概要

• エントリーDOI: 10.2210/pdb2qcf/pdb
• 関連するPDBエントリー: 2jgy 2qcc 2qcd 2qce 2v30
• 分子名称: Uridine 5'-monophosphate synthase (UMP synthase), 5-FLUORO-URIDINE-5'-MONOPHOSPHATE, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: ump synthase, decarboxylase, catalytic proficiency, lyase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28765.09

構造登録者

Wittmann, J.,Rudolph, M. (登録日: 2007-06-19, 公開日: 2007-11-06, 最終更新日: 2021-10-20)

• 主引用文献: Wittmann, J.G.,Heinrich, D.,Gasow, K.,Frey, A.,Diederichsen, U.,Rudolph, M.G.; Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design.; Structure, 16:82-92, 2008; PubMed: 18184586; DOI: 10.1016/j.str.2007.10.020

実験手法

X-RAY DIFFRACTION (1.22 Å)