2QBX

EphB2/SNEW Antagonistic Peptide Complex

2QBX の概要

• エントリーDOI: 10.2210/pdb2qbx/pdb
• 関連するPDBエントリー: 1KGY 1NUK 2BBA
• 分子名称: Ephrin type-B receptor 2, antagonistic peptide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: receptor tyrosine kinase, bi-directional signaling, tumorigenesis, angiogenesis, signaling protein, structural genomics, psi-2, protein structure initiative, accelerated technologies center for gene to 3d structure, atcg3d
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P29323
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 51495.56

構造登録者

Chrencik, J.E.,Brooun, A.,Recht, M.I.,Nicola, G.,Pasquale, E.B.,Kuhn, P.,Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) (登録日: 2007-06-18, 公開日: 2007-11-06, 最終更新日: 2023-08-30)

• 主引用文献: Chrencik, J.E.,Brooun, A.,Recht, M.I.,Nicola, G.,Davis, L.K.,Abagyan, R.,Widmer, H.,Pasquale, E.B.,Kuhn, P.; Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition.; J.Biol.Chem., 282:36505-36513, 2007; PubMed: 17897949; DOI: 10.1074/jbc.M706340200

実験手法

X-RAY DIFFRACTION (2.3 Å)