2QAK

HIV-1 PR mutant in complex with nelfinavir

Summary for 2QAK

• Entry DOI: 10.2210/pdb2qak/pdb
• Related: 2PYM 2PYN 2Q63 2Q64
• Descriptor: PROTEASE RETROPEPSIN, 2-[2-HYDROXY-3-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-4-PHENYL SULFANYL-BUTYL]-DECAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID TERT-BUTYLAMIDE (3 entities in total)
• Functional Keywords: hiv protease inhibitors; protease-inhibitor structure; isothermal calorimetry; antiviral resistance development, hydrolase
• Biological source: human immunodeficiency virus 1 (HIV-1)
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• Total number of polymer chains: 2
• Total formula weight: 22093.20

Authors

Rezacova, P.,Kozisek, M.,Saskova, K.,Brynda, J.,Konvalinka, J. (deposition date: 2007-06-16, release date: 2008-07-01, Last modification date: 2023-08-30)

• Primary citation: Kozisek, M.,Bray, J.,Rezacova, P.,Saskova, K.,Rulisek, L.,Brynda, J.,Pokorna, J.,Mammano, F.,Konvalinka, J.; Evolutionary pathway of HIV resistance analyzed on molecular level: Enzymatic activities, 3-D structures and thermodynamics of HIV proteases resistant to nelfinavir; To be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)