2QAK

HIV-1 PR mutant in complex with nelfinavir

2QAK の概要

• エントリーDOI: 10.2210/pdb2qak/pdb
• 関連するPDBエントリー: 2PYM 2PYN 2Q63 2Q64
• 分子名称: PROTEASE RETROPEPSIN, 2-[2-HYDROXY-3-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-4-PHENYL SULFANYL-BUTYL]-DECAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID TERT-BUTYLAMIDE (3 entities in total)
• 機能のキーワード: hiv protease inhibitors; protease-inhibitor structure; isothermal calorimetry; antiviral resistance development, hydrolase
• 由来する生物種: human immunodeficiency virus 1 (HIV-1)
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22093.20

構造登録者

Rezacova, P.,Kozisek, M.,Saskova, K.,Brynda, J.,Konvalinka, J. (登録日: 2007-06-16, 公開日: 2008-07-01, 最終更新日: 2023-08-30)

• 主引用文献: Kozisek, M.,Bray, J.,Rezacova, P.,Saskova, K.,Rulisek, L.,Brynda, J.,Pokorna, J.,Mammano, F.,Konvalinka, J.; Evolutionary pathway of HIV resistance analyzed on molecular level: Enzymatic activities, 3-D structures and thermodynamics of HIV proteases resistant to nelfinavir; To be Published,

実験手法

X-RAY DIFFRACTION (2.2 Å)