2Q8H
Structure of pyruvate dehydrogenase kinase isoform 1 in complex with dichloroacetate (DCA)
Summary for 2Q8H
| Entry DOI | 10.2210/pdb2q8h/pdb |
| Related | 2Q8F 2Q8G 2Q8I |
| Descriptor | [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, POTASSIUM ION, DICHLORO-ACETIC ACID, ... (4 entities in total) |
| Functional Keywords | ghkl atpase/kinase family, pyruvate dehydrogenase complex, mitochondrial kinase, dichroloacetate, transferase |
| Biological source | Homo sapiens (human) |
| Cellular location | Mitochondrion matrix : Q15118 |
| Total number of polymer chains | 1 |
| Total formula weight | 46529.66 |
| Authors | Kato, M.,Li, J.,Chuang, J.L.,Chuang, D.T. (deposition date: 2007-06-10, release date: 2007-07-24, Last modification date: 2023-08-30) |
| Primary citation | Kato, M.,Li, J.,Chuang, J.L.,Chuang, D.T. Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate, and Radicicol. Structure, 15:992-1004, 2007 Cited by PubMed: 17683942DOI: 10.1016/j.str.2007.07.001 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report
